Raman spectroscopy - advanced optical analysis technology
Boost plant safety, ensure product quality, and optimize operations. Raman spectroscopy measures the composition and molecular structure of your samples from lab-to-process in real time.
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Specs at a glance
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Unit dimensions (width x height x depth)
254 x 102 x 66 mm
10.0 x 4.0 x 2.6 inch -
Sampling probe compatibility
Raman Rxn-10
Field of application
The Raman flow assembly brings in-line Raman spectroscopy to downstream bioprocessing. Comprised of a flow cell and associated flow bench connected to an Rxn-10 probe, this system meets the speed demands of downstream by optimizing Raman collection for low-turbidity, low volume samples. Ideally suited for development-scale flow rates, the Raman flow assembly provides real-time monitoring, rapid process optimization, and process control for chromatography and other downstream unit operations.
Downstream: aggregation, protein crystallization, formula stability, product CQA, protein concentration, buffer excipients
Midstream: analyte monitoring in permeate
Benefits
Brings Raman-based process insights and control to downstream bioprocessing unit operations
Achieves lower limits of detection through enhancement of the Raman signal
Provides continuous, real-time measurements with high sensitivity for development-scale flow rates
Easily connects to an Rxn-10 probe paired with a Raman Rxn embedded analyzer, and ensures transferability when used with the Raman flow assembly calibration and verification kit
With the flow bench, provides flexibility to swap out flow cells any time without impacting your process or sterility
Extended selection
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High-end products
- Highly functional and convenient
Technical excellence
Simplicity
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Standard products
- Reliable, robust and low-maintenance
Technical excellence
Simplicity
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Specialized products
- Designed for demanding applications
Technical excellence
Simplicity
Variable
| FLEX selections | Technical excellence | Simplicity |
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Fundamental selection Meet your basic measurement needs |
Technical excellence
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Simplicity
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Lean selection Handle your core processes easily |
Technical excellence
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Simplicity
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Extended selection Optimize your processes with innovative technologies |
Technical excellence
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Simplicity
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Xpert selection Master your most challenging applications |
Technical excellence
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Simplicity
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12 documents
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Technical Information (TI)
Raman flow assembly Technical Information
System design and specifications for the Raman flow assembly
(KRFB, KRFC)Language:
English
Version:
30/06/2023
File size:
329.5 KB
File name:
TI01721CEN_0123.pdf
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Technical Information (TI)
Raman flow assembly calibration and verification kit Technical Information
System design and specifications for the Raman flow assembly calibration
and verification kitLanguage:
English
Version:
29/06/2023
File size:
430.9 KB
File name:
TI01720CEN_0123 Raman flow assembly calibration and verification kit.pdf
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Operating Instruction (BA)
Raman flow assembly Operating Instructions
Commissioning, operation, and maintenance details for the
Raman flow assembly (KRFB, KRFC)Language:
English
Version:
30/06/2023
File size:
951.5 KB
File name:
BA02296CEN_0123.pdf
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Operating Instruction (BA)
Raman flow assembly calibration and verification kit Operating Instructions
Commissioning, operation, and maintenance details for the
Raman flow assembly calibration and verification kitLanguage:
English
Version:
29/06/2023
File size:
1006.6 KB
File name:
BA02295CEN_0123 Raman flow assembly calibration and verification kit.pdf
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PU (Publication)
Endress+Hauser - your one-source Life Sciences technology partner
Graphic highlighting why Endress+Hauser is trusted by the
world's top biopharmaceutical manufacturers for its Life
Sciences expertise and reliable inline, real-time measurement
technologies like Raman spectroscopy systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology (Liquiline CM44P, CM442 and
OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E,
CLS82E).Language:
English
Version:
27/06/2024
File size:
1.9 MB
File name:
PU01585CEN_0124.pdf
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PU (Publication)
Raman flow assembly - Precise composition measurement of high-speed, low-volume samples in downstream bioprocessing
An overview of the Raman flow assembly (flow bench and flow cell)
used with the Rxn-10 probe in conjunction with a Raman Rxn2
analyzer and a Raman flow assembly calibration and verification kit
for downstream bioprocessing (powered by Kaiser Raman technology).Language:
English
Version:
31/05/2023
File size:
837 KB
File name:
PU01517CEN_0123.pdf
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PU (Publication)
Raman calibration and verification kits - Everything needed to calibrate and verify your Raman analyzer system for lab-to-process scalability
An overview of the Raman calibration and verification kits for
the bio multi optic / single use optic and the Raman flow assembly
(includes the flow bench and flow cell). These kits are to be used in
conjunction with the Rxn-10 probe and Raman Rxn2 / Rxn4 analyzer
for upstream and downstream bioprocessing (powered by Kaiser
Raman technology).Language:
English
Version:
13/12/2023
File size:
2.1 MB
File name:
PU01518CEN_0223.pdf
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PU (Publication)
Lab-to-process monitoring & control in Life Sciences - Reliable measurement of bioprocess physical and chemical properties
A combined product list of analysis offerings from both Optical Analysis
and LIquid Analysis for bioprocessing applications in the life science
industry (including Raman Rxn2 analyzer, Raman Rxn4 analyzer,
Rxn-10 probe, bio multi optic and bio sleeve, Raman flow assembly,
Rxn-45 probe, Rxn-46 probe, Raman optic system for single use,
Memosens CPS61E, Memosens COS81E, OUSBT66, Memosens CPS61E,
Memosens CPS77E, Memosens CLS82E, OUSAF44, Memosens CPS11E,
Memosens CLS16E, TOC Analyzer CA79, Liquiline transmitter platform, and
Memobase software).Language:
English
Version:
11/04/2024
File size:
776.1 KB
File name:
PU01484CEN_0224.pdf
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PU (Publication)
Prioritize scalability for an efficient biopharmaceutical product development lifecycle
This technical paper studies the importance of scalability as a
competitive advantage in bioprocessing in the Life Science industry,
and Endress+Hauser's scalable Raman systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology and Liquid Analysis portfolio
(Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and
Memosens CPS61E, CLS82E, COS81E, CLS82E).Language:
English
Version:
27/06/2024
File size:
754 KB
File name:
PU01584CEN_0124.pdf
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Case Study (CS)
Raman downstream process measurement of biosimilars - Alvotech's monitoring of the protein purification process during ultrafiltration / diafiltration (UF/DF)
This case study examines Alvotech's use of Raman systems
(Raman Rxn2 analyzer with Rxn-10 probe and Raman flow assembly)
to monitor the downstream protein purification process during UF/DF.Language:
English
Version:
11/06/2024
File size:
5.9 MB
File name:
CS01902CEN_0124.pdf
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